Journal
NUCLEIC ACIDS RESEARCH
Volume 38, Issue 19, Pages 6637-6651Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkq454
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Funding
- University of Texas Southwestern Medical Center
- Searle Scholars Program
- National Institutes of Health [GM081882]
- Welch Foundation [I-1643]
- Sara and Frank McKnight fellowship
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Post-transcriptional regulatory mechanisms are widespread in bacteria. Interestingly, current published data hint that some of these mechanisms may be non-random with respect to their phylogenetic distribution. Although small, trans-acting regulatory RNAs commonly occur in bacterial genomes, they have been better characterized in Gram-negative bacteria, leaving the impression that they may be less important for Firmicutes. It has been presumed that Gram-positive bacteria, in particular the Firmicutes, are likely to utilize cis-acting regulatory RNAs located within the 5' mRNA leader region more often than trans-acting regulatory RNAs. In this analysis we catalog, by a deep sequencing-based approach, both classes of regulatory RNA candidates for Bacillus subtilis, the model microorganism for Firmicutes. We successfully recover most of the known small RNA regulators while also identifying a greater number of new candidate RNAs. We anticipate these data to be a broadly useful resource for analysis of post-transcriptional regulatory strategies in B. subtilis and other Firmicutes.
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