Journal
NUCLEIC ACIDS RESEARCH
Volume 38, Issue 15, Pages 5015-5022Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkq280
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Funding
- Institut National du Cancer
- Centre National de la Recherche Scientifique
- Association pour la Recherche contre le Cancer [4859]
- Ligue contre le Cancer (Comite de Paris)
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DNA methylation is an essential epigenetic mark. Three classes of mammalian proteins recognize methylated DNA: MBD proteins, SRA proteins and the zinc-finger proteins Kaiso, ZBTB4 and ZBTB38. The last three proteins can bind either methylated DNA or unmethylated consensus sequences; how this is achieved is largely unclear. Here, we report that the human zinc-finger proteins Kaiso, ZBTB4 and ZBTB38 can bind methylated DNA in a sequence-specific manner, and that they may use a mode of binding common to other zinc-finger proteins. This suggests that many other sequence-specific methyl binding proteins may exist.
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