Journal
NUCLEIC ACIDS RESEARCH
Volume 39, Issue -, Pages D342-D346Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkq1072
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Funding
- US National Science Foundation through its Engineering Research Center Program [EEC-0813570]
- Iowa State University
- Rice University
- University of California, Irvine
- University of New Mexico
- University of Virginia
- University of Wisconsin-Madison
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The ThYme (Thioester-active enzYme; http://www.enzyme.cbirc.iastate.edu) database has been constructed to bring together amino acid sequences and 3D (tertiary) structures of all the enzymes constituting the fatty acid synthesis and polyketide synthesis cycles. These enzymes are active on thioester-containing substrates, specifically those that are parts of the acyl-CoA synthase, acyl-CoA carboxylase, acyl transferase, ketoacyl synthase, ketoacyl reductase, hydroxyacyl dehydratase, enoyl reductase and thioesterase enzyme groups. These groups have been classified into families, members of which are similar in sequences, tertiary structures and catalytic mechanisms, implying common protein ancestry. ThYme is continually updated as sequences and tertiary structures become available.
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