Journal
NUCLEIC ACIDS RESEARCH
Volume 37, Issue 20, Pages 6643-6654Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkp698
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Funding
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health, Department of Health and Human Services [HHSN266200400042C]
- US Department of Energy [DE-AC02-06CH11357]
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We present FIGfams, a new collection of over 100 000 protein families that are the product of manual curation and close strain comparison. Using the Subsystem approach the manual curation is carried out, ensuring a previously unattained degree of throughput and consistency. FIGfams are based on over 950 000 manually annotated proteins and across many hundred Bacteria and Archaea. Associated with each FIGfam is a two-tiered, rapid, accurate decision procedure to determine family membership for new proteins. FIGfams are freely available under an open source license. These can be downloaded at ftp://ftp.theseed.org/FIGfams/. The web site for FIGfams is http://www.theseed.org/wiki/FIGfams/.
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