Journal
NUCLEIC ACIDS RESEARCH
Volume 38, Issue 6, Pages 1866-1873Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkp1179
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Funding
- Wellcome Trust
- Austrian Science Fund (FWF)
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A key step in meiotic recombination involves the nucleolytic resolution of Holliday junctions to generate crossovers. Although the enzyme that performs this function in human cells is presently unknown, recent studies led to the identification of the XPG-family endonuclease GEN1 that promotes Holliday junction resolution in vitro, suggesting that it may perform a related function in vivo. Here, we show that ectopic expression of GEN1 in fission yeast mus81 delta strains results in Holliday junction resolution and crossover formation during meiosis.
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