Journal
NUCLEIC ACIDS RESEARCH
Volume 37, Issue -, Pages D159-D162Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkn772
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Funding
- Centre National de la Recherche Scientifique (CNRS)
- Universite ' Louis Pasteur Strasbourg 1
- Association Francaise contre les Myopathies (AFM)
- Deutsche Forschungsgemeinschaft [MO-634/2, MO-634/3, HA 1672/7-3/4/5, SPP-1174]
- Metazoan Deep Phylogeny [STA 850/3-2]
- French-German PROCOPE program [D/0628236, EGIDE PHC 14770PJ]
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One of the first specialized collections of nucleic acid sequences in life sciences was the 'compilation of tRNA sequences and sequences of tRNA genes' (http://www.trna.uni-bayreuth.de). Here, an updated and completely restructured version of this compilation is presented (http://trnadb.bioinf.uni-leipzig.de). The new database, tRNAdb, is hosted and maintained in cooperation between the universities of Leipzig, Marburg, and Strasbourg. Reimplemented as a relational database, tRNAdb will be updated periodically and is searchable in a highly flexible and user-friendly way. Currently, it contains more than 12 000 tRNA genes, classified into families according to amino acid specificity. Furthermore, the implementation of the NCBI taxonomy tree facilitates phylogeny-related queries. The database provides various services including graphical representations of tRNA secondary structures, a customizable output of aligned or un-aligned sequences with a variety of individual and combinable search criteria, as well as the construction of consensus sequences for any selected set of tRNAs.
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