Journal
NUCLEIC ACIDS RESEARCH
Volume 37, Issue 18, Pages 6239-6248Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkp630
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Funding
- Medical Research Council [G0500336] Funding Source: Medline
- MRC [G0500336] Funding Source: UKRI
- Medical Research Council [G0500336] Funding Source: researchfish
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Short contiguous arrays of variant CTAGGG repeats in the human telomere are unstable in the male germline and somatic cells, suggesting formation of unusual structures by this repeat type. Here, we report on the structure of an intramolecular G-quadruplex formed by DNA sequences containing four human telomeric variant CTAGGG repeats in potassium solution. Our results reveal a new robust antiparallel G-quadruplex fold involving two G-tetrads sandwiched between a G. C base pair and a G center dot C center dot G center dot C tetrad, which could represent a new platform for drug design targeted to human telomeric DNA.
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