Journal
NUCLEIC ACIDS RESEARCH
Volume 37, Issue 4, Pages 1297-1307Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkn1008
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Funding
- Korea Center for Disease Control of the Republic of Korea [091-4845-301-210]
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We define phosphovariants as genetic variations that change phosphorylation sites or their interacting kinases. Considering the essential role of phosphorylation in protein functions, it is highly likely that phosphovariants change protein functions. Therefore, a comparison of phosphovariants between individuals or between species can give clues about phenotypic differences. We categorized phosphovariants into three subtypes and developed a system that predicts them. Our method can be used to screen important polymorphisms and help to identify the mechanisms of genetic diseases.
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