Journal
NUCLEIC ACIDS RESEARCH
Volume 38, Issue 6, Pages 2081-2088Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkp1174
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Funding
- Ministry of Education, Singapore [19/08]
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DNA stretching in the nucleosome core can cause dramatic structural distortions, which may influence compaction and factor recognition in chromatin. We find that the base pair unstacking arising from stretching-induced extreme minor groove kinking near the nucleosome centre creates a hot spot for intercalation and alkylation by a novel anticancer compound. This may have far reaching implications for how chromatin structure can influence binding of intercalator species and indicates potential for the development of site selective DNA-binding agents that target unique conformational features of the nucleosome.
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