Journal
NUCLEIC ACIDS RESEARCH
Volume 38, Issue -, Pages D283-D287Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkp963
Keywords
-
Categories
Funding
- Russian Foundation for Basic Research [08-04-00561]
- Russian Science Support Foundation
- Federal Agency for Science and Innovation [02.740.11.0295]
- NIH, National Library of Medicine
Ask authors/readers for more resources
Most of the proteins in a cell assemble into complexes to carry out their function. In this work, we have created a new database (named ComSin) of protein structures in bound (complex) and unbound (single) states to provide a researcher with exhaustive information on structures of the same or homologous proteins in bound and unbound states. From the complete Protein Data Bank (PDB), we selected 24 910 pairs of protein structures in bound and unbound states, and identified regions of intrinsic disorder. For 2448 pairs, the proteins in bound and unbound states are identical, while 7129 pairs have sequence identity 90% or larger. The developed server enables one to search for proteins in bound and unbound states with several options including sequence similarity between the corresponding proteins in bound and unbound states, and validation of interaction interfaces of protein complexes. Besides that, through our web server, one can obtain necessary information for studying disorder-to-order and order-to-disorder transitions upon complex formation, and analyze structural differences between proteins in bound and unbound states. The database is available at http://antares.protres.ru/comsin/.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available