Journal
NUCLEIC ACIDS RESEARCH
Volume 36, Issue 19, Pages 6260-6268Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkn511
Keywords
-
Categories
Funding
- BBSRC
- Cancer Research UK
- Cambridge Commonwealth Trust and Trinity College
- BBSRC [BB/E019773/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E019773/1] Funding Source: researchfish
Ask authors/readers for more resources
Molecular mechanisms that regulate gene expression can occur either before or after transcription. The information for post-transcriptional regulation can lie within the sequence or structure of the RNA transcript and it has been proposed that G-quadruplex nucleic acid sequence motifs may regulate translation as well as transcription. Here, we have explored the incidence of G-quadruplex motifs in and around the untranslated regions (UTRs) of mRNA. We observed a significant strand asymmetry, consistent with a general depletion of G-quadruplex-forming RNA. We also observed a positional bias in two distinct regions, each suggestive of a specific function. We observed an excess of G-quadruplex motifs towards the 5-ends of 5-UTRs, supportive of a hypothesis linking 5-UTR RNA G-quadruplexes to translational control. We then analysed the vicinity of 3-UTRs and observed an over-representation of G-quadruplex motifs immediately after the 3-end of genes, especially in those cases where another gene is in close proximity, suggesting that G-quadruplexes may be involved in the termination of gene transcription.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available