Journal
NUCLEIC ACIDS RESEARCH
Volume 36, Issue 19, Pages 6155-6164Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkn629
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [16085206, 17GS0316]
- Ministry of Agriculture, Forestry and Fisheries of Japan [GPN0008]
- Grants-in-Aid for Scientific Research [16085206, 17GS0316] Funding Source: KAKEN
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In flowering plants, RNA editing is a posttranscriptional process that converts specific C to U in organelle mRNAs. Nicotiana tabacum is an allotetraploid species derived from the progenitors of Nicotiana sylvestris and Nicotiana tomentosiformis. These Nicotiana species have been used as a model for understanding the mechanism and evolution of RNA editing in plastids. In Nicotiana species, the ndhD-1 site is edited to create the translational initiation codon of ndhD that encodes a subunit of the NAD(P)H dehydrogenease (NDH) complex. An analysis of this RNA editing revealed that editing efficiency in N. tomentosiformis is lower (15) than that in N. tabacum (42) and N. sylvestris (37). However, this level of editing is sufficient for accumulating the NDH complex and its activity. The heterogous complementation of Arabidopsis crr4-3 mutant, in which RNA editing of ndhD-1 is completely impaired, with CRR4 orthologous genes derived from Nicotiana species suggested that the reduction in editing efficiency in N. tomentosiformis is caused by amino acid variations accumulating in CRR4.
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