Journal
SURVEY OF OPHTHALMOLOGY
Volume 60, Issue 1, Pages 60-71Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.survophthal.2014.06.001
Keywords
herpes simplex virus-1; cornea; lymphangiogenesis; vascular endothelial growth factor (VEGF); neovascularization
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Funding
- National Institutes of Health [AI081869, EY021886, EY023691, VA I01 BX002386, UL1TR000050, EY01792]
- Research to Prevent Blindness, New York, NY
- Illinois Society for the Prevention of Blindness (PIP)
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Corneal lymphangiogenesis is the extension of lymphatic vessels into the normally alymphatic cornea, a process that compromises the cornea's immune-privileged state and facilitates herpetic stromal keratitis (HSK). HSK results most commonly from infection by herpes simplex virus-1 (HSV-1) and is characterized by immune- and inflammation-mediated damage to the deep layers of the cornea. Current research demonstrates the potential of anti-lymphangiogenic therapy to decrease and prevent herpes-induced lymphangiogenesis. (C) 2015 Elsevier Inc. All rights reserved.
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