Journal
NUCLEAR MEDICINE AND BIOLOGY
Volume 39, Issue 4, Pages 551-559Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nucmedbio.2011.10.006
Keywords
Aqueous Biphasic Extraction Chromatography; Automation; Medical radionuclides; Technetium-99m; Pertechnetate
Funding
- National Sciences and Engineering Research Council of Canada [RMIPJ 389546-09]
- Canadian Institutes of Health Research [MIS-100934]
- Michael Smith Foundation for Health Research
- BC Leading Edge Endowment Fund
- TRIUMF
- Natural Resources Canada
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Introduction: The shortage of reactor-produced molybdenum-99 (Mo-99, t(1/2),=66 h) has renewed interest in alternative production methods of its daughter isotope, technetium-99m ((99)mTc, t(1/2)=6.02 h). While adsorption chromatography serves as a mechanism for selective elution of sodium pertechnetate from technetium generators, this method of purification is not sufficient for many alternative production methods. Several ion-separation/solid phase extraction chromatography methods are known, yet none have been demonstrated on cyclotron-produced [Tc-99m]TcO4(-). Herein we describe the design, manufacture and optimization of a remotely operated module for the purification or sodium pertechnetate from a bulk solution of molybdate. Methods: The automated purification module was designed to separate [Tc-99m]TcO4- using either Dowex 1x8 or an Aqueous Biphasic Extraction Chromatography (ABEC) resin. Mo-100 composite targets were irradiated with 18.5 MeV protons for 10 mu A.h using an ASCI TR19 cyclotron. Once purified, the radiopharmaceutical quality of (TcO4-)-Tc-99m isolated from each process (Dowex and/or ABEC) was established by assaying for molybdate breakthrough, alumina levels and, in the case of the Dowex approach, residual organics. Results: The separation processes are efficient (75% for Dowex, 90% for ABEC) and complete in less than 30 min. Overall, up to 2.1 GBq of Tc-99m was produced using the (100)(p,2n)Tc-99m transformation, processed using the separation module and subjected to a detailed chemical and radionuclidic analysis. Due to its expense and limited availability, (MoO42-)-Mo-100 was recovered in >90% yield using a precipitation/filtration/lyophilization approach. Conclusions: Na[Tc-99m]TcO4 was produced using a medical cyclotron, recovered using an automated purification module and found to exceed all established quality control parameters. (C) 2012 Elsevier Inc. All rights reserved.
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