4.4 Article

Carbon nanotube based X-ray sources: Applications in pre-clinical and medical imaging

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.nima.2010.11.053

Keywords

Micro-computed tomography; Pre-clinical imaging; Tomosynthesis

Funding

  1. NIH-NCI [U54CA119343]
  2. NIH-NIBIB [4R33EB004204-01]
  3. UNC University Cancer Research Fund
  4. Xintek, Inc.

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Field emission offers an alternate method of electron production for Bremsstrahlung based X-ray tubes. Carbon nanotubes (CNTs) serve as very effective field emitters, allowing them to serve as electron sources for X-ray sources, with specific advantages over traditional thermionic tubes. CNT derived X-ray sources can create X-ray pulses of any duration and frequency, gate the X-ray pulse to any source and allow the placement of many sources in close proximity. We have constructed a number of micro-CT systems based on CNT X-ray sources for applications in small animal imaging, specifically focused on the imaging of the heart and lungs. This paper offers a review of the pre-clinical applications of the CNT based micro-CT that we have developed. We also discuss some of the current and potential clinical applications of the CNT X-ray sources. (c) 2010 Elsevier B.V. All rights reserved.

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