Journal
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
Volume 648, Issue -, Pages S236-S240Publisher
ELSEVIER
DOI: 10.1016/j.nima.2010.11.092
Keywords
PET; Spatial resolution
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Funding
- Office of Science, Office of Biological and Environmental Research, Medical Science Division of the U.S. Department of Energy [DE-AC02-05CH11231]
- National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering [R01-EB006085, R21-EB007081]
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The fundamental limits of spatial resolution in positron emission tomography (PET) have been understood for many years. The physical size of the detector element usually plays the dominant role in determining resolution, but the combined contributions from acollinearity, positron range, penetration into the detector ring, and decoding errors in the detector modules often combine to be of similar size. In addition, the sampling geometry and statistical noise further degrade the effective resolution. This paper quantitatively describes these effects, discusses potential methods for reducing the magnitude of these effects, and computes the ultimately achievable spatial resolution for clinical and pre-clinical PET cameras. (c) 2010 Elsevier B.V. All rights reserved.
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