Toward integrated laser-driven ion accelerator systems at the photo-medical research center in Japan

Goals and early progress at the Photo-Medical Research Center are summarized. Laser-driven ion beam radiotherapy can require compact repetition-rated laser systems with peak powers approaching the PW level. Laser development at PMRC is outlined. Our parallel experimental and simulation efforts aimed at the development of a prototype ion beamline as an integrated laser-driven ion accelerator system are presented. In addition some of our first medical and radiobiological experimental investigations, proton-induced double strand breaking in human cancer cells and simulations of optimum dose distributions for ocular melanoma are discussed. Recommended components of a balanced and comprehensive PMRC agenda are given. (C) 2010 Elsevier B.V. All rights reserved.