Journal
NMR IN BIOMEDICINE
Volume 27, Issue 9, Pages 1019-1029Publisher
WILEY
DOI: 10.1002/nbm.3147
Keywords
Amide proton transfer (APT) imaging; chemical exchange saturation transfer (CEST) imaging; magnetization transfer (MT) imaging; pH; MRI; stroke
Funding
- Qualcomm Scholarship from Qualcomm Inc.
- National Institute for Health Research (NIHR) Oxford Biomedical Research Centre Programme
- Dunhill Medical Trust [OSRP1/1006]
- Centre of Excellence for Personalised Healthcare - Wellcome Trust
- Engineering and Physical Sciences Research Council (EPSRC) [WT 088877/Z/09/Z]
- Engineering and Physical Sciences Research Council [EP/K025716/1] Funding Source: researchfish
- Medical Research Council [G0701128] Funding Source: researchfish
- The Dunhill Medical Trust [OSRP1/1006] Funding Source: researchfish
- EPSRC [EP/K025716/1] Funding Source: UKRI
- MRC [G0701128] Funding Source: UKRI
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Amide proton transfer (APT) imaging is a pH mapping method based on the chemical exchange saturation transfer phenomenon that has potential for penumbra identification following stroke. The majority of the literature thus far has focused on generating pH-weighted contrast using magnetization transfer ratio asymmetry analysis instead of quantitative pH mapping. In this study, the widely used asymmetry analysis and a model-based analysis were both assessed on APT data collected from healthy subjects (n = 2) and hyperacute stroke patients (n = 6, median imaging time after onset = 2 hours 59 minutes). It was found that the model-based approach was able to quantify the APT effect with the lowest variation in grey and white matter (<= 13.8 %) and the smallest average contrast between these two tissue types (3.48 %) in the healthy volunteers. The model-based approach also performed quantitatively better than the other measures in the hyperacute stroke patient APT data, where the quantified APT effect in the infarct core was consistently lower than in the contralateral normal appearing tissue for all the patients recruited, with the group average of the quantified APT effect being 1.5 +/- 0.3 % (infarct core) and 1.9 +/- 0.4 % (contralateral). Based on the fitted parameters from the model-based analysis and a previously published pH and amide proton exchange rate relationship, quantitative pH maps for hyperacute stroke patients were generated, for the first time, using APT imaging. (C) 2014 The Authors. NMR in Biomedicine published by John Wiley & Sons, Ltd.
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