Journal
NMR IN BIOMEDICINE
Volume 22, Issue 8, Pages 867-873Publisher
WILEY
DOI: 10.1002/nbm.1401
Keywords
hyperpolarization; C-13; metabolic imaging; parallel imaging
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The ability to accelerate the spatial encoding process during a chemical shift imaging (CSI) scan of hyperpolarized compounds is demonstrated through parallel imaging. A hardware setup designed to simultaneously acquire C-13 data from multiple receivers is presented here. A system consisting of four preamplifiers, four gain stages, a transmit coil, and a four receive channel rat coil was built for single channel excitation and simultaneous multi-channel detection of C-13 signals. The hardware setup was integrated with commercial scanner electronics, allowing the system to function similar to a conventional proton multi-channel setup, except at a different frequency. The ability to perform parallel imaging is demonstrated in vivo. CSI data from the accelerated scans are reconstructed using a self-calibrated multi-spectral parallel imaging algorithm, by using lower resolution coil sensitivity maps obtained from the central region of k-space. The advantages and disadvantages of parallel imaging in the context of imaging hyperpolarized compounds are discussed. Copyright (C) 2009 John Wiley & Sons, Ltd.
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