Journal
NMR IN BIOMEDICINE
Volume 21, Issue 9, Pages 978-996Publisher
WILEY
DOI: 10.1002/nbm.1311
Keywords
choroid; retinal blood flow; BOLD; functional MRI; diffusion-weighted MRI; high resolution imaging; retinal diseases; manganese-enhanced MRI (MEMRI)
Funding
- NIH/NEI [R01 EY014211, 1130 EY006360]
- Whitaker Foundation [RG-02-0005]
- MERIT
- Department of Veterans Affairs, Emory University Research Committee
- Woodruff Health Science Center
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Most retinal imaging has been performed using optical techniques. This paper reviews alternative retinal imaging methods based on MRI performed with spatial resolution sufficient to resolve multiple well-defined retinal layers. The development of these MRI technologies to study retinal anatomy, physiology (blood flow, blood volume, and oxygenation) and function, and their applications to the study of normal retinas, retinal degeneration and diabetic retinopathy in animal models are discussed. Although the spatiotemporal resolution of MRI is poorer than that of optical imaging techniques, it is unhampered by media opacity and can thus image all retinal and pararetinal structures, and has the potential to provide multiple unique clinically relevant data in a single setting and could thus complement existing retinal imaging techniques. In turn, the highly structured retina with well-defined layers is an excellent model for advancing emerging high-resolution anatomical, physiological and functional MRI technologies. Copyright (C) 2008 John Wiley & Sons. Ltd.
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