Journal
NMR IN BIOMEDICINE
Volume 21, Issue 8, Pages 820-829Publisher
WILEY
DOI: 10.1002/nbm.1260
Keywords
phagocytosis; iron oxide; tumor necrosis factor; migration; cytokine; viability; proliferation
Funding
- National Science Council of the Republic of China [NSC-93-2314-B-002-136, NSC-96-2321-B-002-019, NSC-94-2314-B-002-204]
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Our goal was to analyze the changes in morphology and physiological function (phagocytosis, migratory capabilities, humoral and cellular response, and nitric oxide secretion) of murine macrophages after labeling with a clinically used superparamagnetic iron oxide (SPIO), ferucarbotran. In SPIO-treated macrophages, nanoparticles were taken up in the cytoplasm and accumulated in a membrane-bound organelle. Macrophage proliferation and viability were not modified after SPIO labeling. Phagocytic function decreased after labeling with only 10 mu g Fe/mL SPIO, whereas other functions including migration and production of tumor necrosis factor-a and nitric oxide increased at the highest SPIO concentration (100 mu g Fe/mL). Copyright (C) 2008 John Wiley & Sons. Ltd.
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