Journal
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
Volume 23, Issue 1, Pages 60-64Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.niox.2010.04.003
Keywords
Nitric oxide; Liposome; Zwitterionic diazeniumdiolate; Activated release; Heat; Nanovehicle
Categories
Funding
- National Health Research Institutes, Taiwan [NHRI-97-NM-PP-05, NHRI-98-NM-PP-05]
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Zwitterionic diazeniumdiolate, a nitric oxide precursor, was dissolved in basic buffer solution (pH = 9.0) and encapsulated in thermo-sensitive liposomes composed of phospholipids of different sensitive temperatures. The basic intra-liposomal environment dramatically delayed spontaneous NO release. When the liposomes were placed in physiological buffer solution and temperatures were increased to the sensitive temperatures of the phospholipids' membranes, extra-liposomal protons started to influx to collapse the pH gradient and subsequently induce a significant NO release. Moreover, the presence of a stronger pH gradient when the liposomes were applied to a more acidic environment caused a higher proton influx driving force to trigger the influx of protons and, subsequently, NO release. In this work, we demonstrate that thermo-sensitive liposomes can be used to create a stable pH gradient in a nanoenvironment entrapping zwitterionic diazeniumdiolate for sustained and heat/acid-activated NO release. (C) 2010 Elsevier Inc. All rights reserved.
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