Journal
NICOTINE & TOBACCO RESEARCH
Volume 13, Issue 10, Pages 982-988Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ntr/ntr106
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Funding
- Cancer Research UK [C53/A6281]
- National Institutes of Health (National Institute on Drug Abuse) Department of Health and Human Services, USA
- National Institute of Health Research
- Economic and Social Research Council
- British Heart Foundation
- Cancer Research UK
- Department of Health
- Medical Research Council of the UK Clinical Research
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Introduction: The rs1051730 genetic variant within the CHRNA5-A3-B4 gene cluster is associated with heaviness of smoking and has recently been reported to be associated with likelihood of stopping smoking. We investigated the potential association of rs1051730 genotype with reduced likelihood of smoking cessation in 2 cohorts of treatment-seeking smokers in primary care in the United Kingdom. Methods: Data were drawn from 2 clinical trials on which DNA was available. One sample was a randomized placebo-controlled trial of nicotine transdermal patch and the other sample an open-label trial where all participants received nicotine transdermal patch. Smoking status was biochemically verified. Logistic regression was used to assess evidence for association in each sample, and data were combined within a meta-analysis. Results: There was evidence of association of rs1051730 genotype with short-term (4-week) cessation in our open-label trial sample but not our placebo-controlled trial sample. When combined in a meta-analysis, this effect remained. There was no evidence of association at later follow-up intervals. Adjustment for cigarette consumption and tobacco dependence did not alter these results substantially. Conclusions: Our data, taken together with previous recent studies, provide some support for a weak association between this variant and short-term smoking cessation in treatment-seeking smokers, which does not seem to operate only among those receiving nicotine replacement therapy. Moreover, the rs1051730 variant may not merely operate as a marker for dependence or heaviness of smoking.
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