Journal
NEW PHYTOLOGIST
Volume 221, Issue 4, Pages 2080-2095Publisher
WILEY
DOI: 10.1111/nph.15497
Keywords
Arabidopsis; immune receptor; immune signaling comparison; plant immunity; receptor kinase; receptor protein
Categories
Funding
- Deutsche Forschungsgemeinschaft [SFB1101, Nu70/15-1, Gu 1034/3-1]
- Gatsby Charitable Foundation
- European Research Council (grant 'PHOSPHinnATE')
- NIH [R01GM097247]
- Robert A. Welch foundation [A-1795]
- Max Planck Society
- CellNetworks research group funds
- Heidelberg University
- BBSRC [BBS/E/J/000PR9796, BBS/E/J/000PR9795] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000PR9795, BBS/E/J/000PR9796] Funding Source: researchfish
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Pattern recognition receptors (PRRs) sense microbial patterns and activate innate immunity against attempted microbial invasions. The leucine-rich repeat receptor kinases (LRR-RK) FLS2 and EFR, and the LRR receptor protein (LRR-RP) receptors RLP23 and RLP42, respectively, represent prototypical members of these two prominent and closely related PRR families. We conducted a survey of Arabidopsis thaliana immune signaling mediated by these receptors to address the question of commonalities and differences between LRR-RK and LRR-RP signaling. Quantitative differences in timing and amplitude were observed for several early immune responses, with RP-mediated responses typically being slower and more prolonged than those mediated by RKs. Activation of RLP23, but not FLS2, induced the production of camalexin. Transcriptomic analysis revealed that RLP23-regulated genes represent only a fraction of those genes differentially expressed upon FLS2 activation. Several positive and negative regulators of FLS2-signaling play similar roles in RLP23 signaling. Intriguingly, the cytoplasmic receptor kinase BIK1, a positive regulator of RK signaling, acts as a negative regulator of RP-type immune receptors in a manner dependent on BIK1 kinase activity. Our study unveiled unexpected differences in two closely related receptor systems and reports a new negative role of BIK1 in plant immunity.
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