Journal
NEW PHYTOLOGIST
Volume 186, Issue 1, Pages 54-62Publisher
WILEY
DOI: 10.1111/j.1469-8137.2009.03087.x
Keywords
aneuploidy; cis-trans regulation; gene balance hypothesis; hybrid incompatibilities; interactome; polyploidy; quantitative traits
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Funding
- NSF [DBI 0733857]
- NIH [RO1GM068042]
- CNRS
- Universite Paris-Diderot
- Institut Universitaire de France
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM068042] Funding Source: NIH RePORTER
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P>The gene balance hypothesis states that the stoichiometry of members of multisubunit complexes affects the function of the whole because of the kinetics and mode of assembly. Gene regulatory mechanisms also would be governed by these principles. Here, we review the impact of this concept with regard to the effects on the genetics of quantitative traits, the fate of duplication of genes following polyploidization events or segmental duplication, the basis of aneuploid syndromes, the constraints on cis and trans variation in gene regulation and the potential involvement in hybrid incompatibilities.
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