Journal
STROKE
Volume 46, Issue 7, Pages 1777-1786Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.115.009111
Keywords
coronary heart disease; homocysteine; hypertension; ischemia; stroke
Categories
Funding
- Shenzhen Nanshan Bureau of Science and Technology [2010058]
- K.C. Wong Magna Fund in Ningbo University
- National Natural Science Foundation of China [81402745]
- Natural Science Foundation of Ningbo City [2014A610268]
- Key Program of Education Commission of Zhejiang Province [Z201017918]
- Natural Science Foundation of Zhejiang Province [LQ13H260002]
- Zhejiang Province Scientific Research Projects of Education [Y201326971]
- Ministry of Education, Humanities and Social Sciences project [14YJC630046]
- China Medical Board Health Project [08-929]
- China Medical Board Distinguished Professorships Project [G16916400/F510000]
Ask authors/readers for more resources
Background and Purpose Total homocysteine level (tHcy) is a risk factor of ischemic stroke (IS) and coronary heart disease. However, the results are conflicting and mainly focused on healthy individuals in developed countries. Methods A prospective, population-based cohort study was conducted among 5935 participants from 60 communities in the city of Shenzhen, China. A Cox regression analysis was applied to evaluate the contribution of tHcy to the risk of IS and coronary heart disease. The effect of folic acid supplementation on tHcy levels was also evaluated among 501 patients with essential hypertension, who received an average of 2.5 years of folic acid supplementation. Results After adjustment for confounding factors, the hazard ratios (95% confidence intervals) of IS caused by hyperhomocysteinemia were 2.18 (1.65-2.89), 2.40 (1.56-3.67), and 2.73 (1.83-4.08) in the total, male, and female participants, respectively. Compared with normal levels of tHcy (<15 mol/L), the hazard ratios (95% confidence intervals) for IS in the highest tHcy category (30 mol/L) were 4.96 (3.03-8.12), 6.11 (3.44-10.85), and 1.84 (0.52-6.46) in the total, males, and females participants, respectively. However, we did not observe a significant relationship between tHcy and the risk of coronary heart disease. The 2.5 years of folic acid supplementation reduced tHcy levels by 6.7 mol/L (27.92%) in patients with essential hypertension. Conclusions Hyperhomocysteinemia in Chinese hypertensive patients is significantly associated with IS risk but not coronary heart disease susceptibility, and folic acid supplementation can efficiently reduce tHcy levels.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available