Journal
NEW JOURNAL OF CHEMISTRY
Volume 42, Issue 16, Pages 13784-13789Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nj02388c
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Funding
- CSIC Grupos [654, 983]
- PEDECIBA Quimica
- Spanish MINECO
- European Regional Development Fund (ERDF) [CTQ2014-56362-C2-1-P]
- ANII (Agencia Nacional de Investigacion e Innovacion)
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Inspired by diverse marine bioactive compounds, the principle of molecular hybridization was applied to produce a series of new compounds combining diverse heterocyclic systems (oxa/thiazoles and tetrahydropyrans) via a triazole ring, attempting to increase the activity of individual building blocks. These new compounds exhibit a highly interesting antiproliferative activity against different human tumour cells and good selectivity when compared to normal cells. The formation of reactive oxygen species and the interaction with P-gp were also evaluated for the lead compounds.
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