4.6 Article

Asymmetric direct aldol reactions catalyzed by chiral amine macrocycle-metal(II) complexes under solvent-free conditions

Journal

NEW JOURNAL OF CHEMISTRY
Volume 37, Issue 9, Pages 2851-2855

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nj00361b

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Funding

  1. Grants-in-Aid for Scientific Research [23550129] Funding Source: KAKEN

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Solvent-free asymmetric aldol reactions between cyclohexanone and 4-nitrobenzaldehyde using chiral amine macrocycle-metal(II) complexes as catalysts in a ball mill afforded the anti-aldol product as the major isomer with up to 93% ee.

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