Journal
NEW JOURNAL OF CHEMISTRY
Volume 36, Issue 2, Pages 419-427Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1nj20476a
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Funding
- National Institutes of Health [GM087448]
- American Chemical Society [48907-ND4]
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Convergent syntheses of polyglycerol hyperbranched polymers containing fluorescent labels (fluorescein or perylene diimide (PDI)) at their core are presented. The hyperbranched polyglycerol (HPG) precursors were synthesized using a one step polymerization reaction wherein the initiator leaves a single reactive group for dye functionalization. For further site isolation, allylated HPG was synthesized allowing cross-linking via ring closing metathesis and subsequent dihydroxylation to produce water-soluble, fluorescent nanoparticles. The dyes produced showed improvements in photostability, water solubility, or quantum yield, depending on both the dye used and cross-linking. These fluorescent nanoparticles outperformed similar dyes that incorporated linear polyethylene glycol (PEG) polymers.
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