Journal
NEW JOURNAL OF CHEMISTRY
Volume 34, Issue 2, Pages 348-354Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b9nj00498j
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Funding
- Welch Foundation [F1151, F1193]
- National Institutes of Health [GM077437, EB00549, GM58907]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000549] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM077437, R01GM058907] Funding Source: NIH RePORTER
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The determination of binding constants is central to many areas of research, supramolecular chemistry in particular. Traditional nonlinear regression analysis, however, cannot be applied to complex systems unless certain assumptions are undertaken, which often limits the reliability of such calculations. Our group has developed an iterative method using commercial software that allows for the rigorous determination of binding constants in a variety of systems, including 1 : 2 complexes, indicator displacement assays, and enantioselective indicator displacement assays. The improved accuracy of the values obtained in the latter case, in turn, allows for a more precise determination of ee in competitive equilibria.
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