Journal
NEW JOURNAL OF CHEMISTRY
Volume 34, Issue 9, Pages 2040-2046Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0nj00067a
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- Regional Innovation Center for Next Generation Industrial Radiation Technology at Wonkwang University
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In this study, we prepared biocompatible, water-soluble, superparamagnetic, manganese-doped, magnetism-engineered iron oxide (MnMEIO) nanocrystals with reactive moieties. This was achieved via a one-pot synthesis protocol by thermally decomposing metal acetylacetonate precursors in 2-pyrrolidone in the presence of polyethylene glycol diacid. Using carbodiimide, we achieved nanocrystals coupled with 9-aminoacridine and folic acid through 2,2'-(ethylenedioxy)-bis-ethylamine. The results suggest that the nanocrystals provide carboxyl functional groups as binding sites. Their surface modification and composition were analyzed by Fourier transform infrared (FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS), respectively. Using Mossbauer spectroscopy and a magnetometer, we have shown that these nanocrystals exhibit superparamagnetic behaviors. In addition, we have demonstrated that the nanocrystals were not significantly toxic, and hence are biocompatible.
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