Journal
NEW JOURNAL OF CHEMISTRY
Volume 33, Issue 5, Pages 1087-1093Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b820632p
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Funding
- Malvern Instruments Zetasizer 2000
- POLPHARMA Foundation [12/04/2005]
- Polish Pharmacy and Medicine [2 P05F 008 30]
- Polish Ministry of Science and Higher Education
- NATO [CBP.EAP.CLG.981751]
- Polish-Italian bilateral
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Heparin is involved in the pathogenesis of prion diseases, affecting the process of fibril formation. It has been shown that whether it accelerates or inhibits fibrilogenesis depends on its concentration: prion peptide PrP 185-208 aggregates in the presence of 0.04 mg ml(-1) heparin, but concentrations ten times lower or higher cause no aggregation. Polyamidoamine, polypropyleneimine and phosphorus dendrimers that previously exhibited anti-prion activity have been shown to interact with heparin. The interactions between cationic dendrimers and anionic heparin are mainly electrostatic. The present study shows that these interactions are indirectly responsible for the inhibition or enhancement of fibril formation by dendrimers.
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