Journal
NEW ENGLAND JOURNAL OF MEDICINE
Volume 369, Issue 7, Pages 678-678Publisher
MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMc1307641
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To the Editor: In their article on the use of sofosbuvir in previously untreated patients with chronic hepatitis C virus (HCV) infection in two phase 3 studies (May 16 issue),(1) Lawitz et al. conclude that the addition of sofosbuvir was effective in patients who were infected with HCV genotype 1, 4, 5, or 6 (NEUTRINO trial). However, response rates in the group that received sofosbuvir and ribavirin were lower among patients with genotype 3 infection than among those with genotype 2 infection (FISSION trial). Although for the latter trial, the authors provide data on the presence or absence of cirrhosis, ...
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