Journal
NEW ENGLAND JOURNAL OF MEDICINE
Volume 366, Issue 10, Pages 925-931Publisher
MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMoa1112824
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Funding
- National Institutes of Health [RC2CA148468]
- American Cancer Society [MRSG-11-054-01-LIB]
- Melanoma Research Alliance
- Swim Across America
- Cancer Research Institute
- Virginia and D.K. Ludwig Fund for Cancer Research
- Lita Annenberg Hazen Foundation
- Commonwealth Foundation for Cancer Research
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The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage with antibody responses to the cancertestis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibody responses to other antigens after radiotherapy. (Funded by the National Institutes of Health and others.)
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