Journal
NEW ENGLAND JOURNAL OF MEDICINE
Volume 365, Issue 8, Pages 718-724Publisher
MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMoa1107643
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Funding
- State Key Development Program for Basic Research of China [2009CB522600]
- National Key Program for Infectious Diseases of China [2008ZX10004-009]
- Shenzhen Biological Industry Development Special Foundation [JC201005250088A]
- Shenzhen City [ZD200806180054A]
- European Union [FP7-KBBE-2007-3-2-08-222886]
- Alexander von Humboldt Foundation
- Medical Faculty of the University Medical Center Hamburg-Eppendorf
- British Biotechnology and Biological Sciences Research Council [BB/E011179/1]
- Biotechnology and Biological Sciences Research Council [BB/E011179/1] Funding Source: researchfish
- BBSRC [BB/E011179/1] Funding Source: UKRI
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An outbreak caused by Shiga-toxin-producing Escherichia coli O104:H4 occurred in Germany in May and June of 2011, with more than 3000 persons infected. Here, we report a cluster of cases associated with a single family and describe an open-source genomic analysis of an isolate from one member of the family. This analysis involved the use of rapid, bench-top DNA sequencing technology, open-source data release, and prompt crowd-sourced analyses. In less than a week, these studies revealed that the outbreak strain belonged to an enteroaggregative E. coli lineage that had acquired genes for Shiga toxin 2 and for antibiotic resistance.
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