Journal
STEROIDS
Volume 98, Issue -, Pages 80-91Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2015.03.001
Keywords
Androstenedione; Thiazole; Thiophene; Pyran; Anti-inflammatory; Anti-ulcer
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The reaction of androstenedione with bromine gave the 16-bromo derivative 2. The latter reacted with either cyanothioacetamide or thiourea to give the 2-cyanomethylthiazole derivative 4 and the 2-aminothiazole derivative 13. Compound 4 and 13 were used underwent some condensation, coupling and heterocyclization reactions to give thiophene, pyridine and pyran derivatives. The anti-inflammatory and anti-ulcer evaluations of the newly synthesized products were evaluated and the results showed that 23f showed the maximum antiulcer activity. In addition, toxicity of the most active compounds was studied against shrimp larvae and showed that compounds 2, 23c and 23f showed non-toxicity against the tested organisms. (C) 2015 Elsevier Inc. All rights reserved.
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