Journal
STEROIDS
Volume 98, Issue -, Pages 132-137Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2015.03.013
Keywords
Steroid sapogenins; Spirochromenes; Radical scavengers; Antioxidant activity; DPPH test
Funding
- Direccion General de Asuntos del Personal Academic [DGAPA-IN211714, IN210713]
- Faculty of Chemistry [PAIP-5000-9063, 5000-9105]
- CONACYT-Mexico
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Tandem aldol condensation between steroid sapogenins and hydroxylated benzaldehydes afforded steroidal spirochromenes. Compounds that bear a phenolic hydroxyl group at position C-6', obtained by a reaction with 2,5-dihydroxybenzaldehyde, showed approximately 80% of maximal radical scavenging activity in the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) assay at 288 nM. In contrast, the starting steroid sapogenins and the spirochromenes without a phenolic group in the side chain proved to be inactive. (C) 2015 Elsevier Inc. All rights reserved.
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