Journal
NEW ENGLAND JOURNAL OF MEDICINE
Volume 358, Issue 25, Pages 2698-2703Publisher
MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMoa0800251
Keywords
-
Categories
Funding
- NCI NIH HHS [R01 CA104711, R21 CA128283-02, CA12823, CA1047113, R01 CA104711-05, R21 CA128283] Funding Source: Medline
- NCRR NIH HHS [M01 RR000037-47, M01 RR000037] Funding Source: Medline
Ask authors/readers for more resources
We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available