Journal
STEM CELLS
Volume 33, Issue 3, Pages 627-638Publisher
OXFORD UNIV PRESS
DOI: 10.1002/stem.1909
Keywords
Mesenchymal stem cells; Dental stem cells; Tissue regeneration; Immunomodulation; Cell-based therapy; Dental stem cell banks
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Funding
- Ministry of Science and Technology of China [2013CB967500, 2011CB966200]
- National Natural Science Foundation of China [31170824]
- Natural Science Foundation of Shanghai [12ZR1434200]
- Science and Technology Commission of Shanghai Municipality [124119a7400]
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Recently, numerous types of human dental tissue-derived mesenchymal stem cells (MSCs) have been isolated and characterized, including dental pulp stem cells, stem cells from exfoliated deciduous teeth, periodontal ligament stem cells, dental follicle progenitor cells, alveolar bonederived MSCs, stem cells from apical papilla, tooth germ progenitor cells, and gingival MSCs. All these MSC-like cells exhibit self-renewal, multilineage differentiation potential, and immunomodulatory properties. Several studies have demonstrated the potential advantages of dental stem cell-based approaches for regenerative treatments and immunotherapies. This review outlines the properties of various dental MSC-like populations and the progress toward their use in regenerative therapy. Several dental stem cell banks worldwide are also introduced, with a view toward future clinical application.
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