Journal
STEM CELLS
Volume 33, Issue 10, Pages 2903-2912Publisher
WILEY
DOI: 10.1002/stem.2056
Keywords
Adult stem cells; Cell cycle; Quiescence; Hematopoietic stem cells; Marrow stromal cells; Muscle stem cells; Differentiation
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Funding
- Indo-Denmark Collaborative Grant from the Danish Strategic Research Council
- Government of India, Department of Biotechnology
- Institute for Stem Cell Biology and Regenerative Medicine
- Government of India, Council for Scientific and Industrial Research
- NovoNordisk Foundation
- Lundbeck Foundation
- Novo Nordisk Fonden [NNF15CC0018344] Funding Source: researchfish
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Adult stem cells (ASCs) are tissue resident stem cells responsible for tissue homeostasis and regeneration following injury. In uninjured tissues, ASCs exist in a nonproliferating, reversibly cell cycle-arrested state known as quiescence or G0. A key function of the quiescent state is to preserve stemness in ASCs by preventing precocious differentiation, and thus maintaining a pool of undifferentiated ASCs. Recent evidences suggest that quiescence is an actively maintained state and that excessive or defective quiescence may lead to compromised tissue regeneration or tumorigenesis. The aim of this review is to provide an update regarding the biological mechanisms of ASC quiescence and their role in tissue regeneration.
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