Journal
STEM CELL REVIEWS AND REPORTS
Volume 11, Issue 5, Pages 706-709Publisher
SPRINGER
DOI: 10.1007/s12015-015-9603-y
Keywords
Oxidative stress; Adult neurogenesis; Ageing; Neurodegeneration
Funding
- Hundred Talents program
- Jiangsu Provincial Natural Science Foundation [BK20140917]
- National Natural Science Foundation of China [81171853, 81472163]
- Qing Lan Project of Nanjing Normal University
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There is a growing evidence that adult neurogenesis is critical for brain function. The reactive oxygen species (ROS) is accumulated during adult neurogenesis as a physiological mechanism; while ROS overload impairs adult neurogenesis during ageing, neuroinflammation and neurodegeneration. Here we propose that targeting oxidative stress provides a novel way to regulate adult neurogenesis and manage different brain diseases.
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