Journal
NEUROTOXICOLOGY AND TERATOLOGY
Volume 30, Issue 6, Pages 468-474Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ntt.2008.07.002
Keywords
Organophosphates; Neurotoxicity; Maternal behavior; Maternal aggression; Anxiety
Categories
Funding
- grant Istituto Superiore di SanitA-Istituto Superiore Prevenzione e Sicurezza Sul Lavoro (ISS-ISPESL)
- ISSNational Institute of Health [ISS-NIH 0F14]
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CD-1 mice were exposed to the organophosphate pesticide chlorpyrifos (CPF) throughout postnatal days (PND) 11-14 at the subtoxic dose of 3 mg/kg. At adolescent age, females and mates underwent a sociability test in which level of sociability and social preference were measured. At adulthood only females' behavior was analyzed. Maternal behavior of CPF-exposed females was assessed on postpartum day 1 after removal of the pups for I h, while anxiety levels were measured in a 5 min dark-light test on postpartum day 2. Nest defense response to an unfamiliar male intruder was assessed on postpartum day 7. In addition, from birth to postpartum day 7 a detailed analysis of nest building activity was carried out Neonatal CPF exposure does not interfere with social behavior and social preferences at adolescence, whereas at adulthood it induces significant behavioral alterations in lactating females. Motivation to build and defend the nest was decreased in CPF females that were also less anxious than controls in the dark-light paradigm. These results confirm that developmental exposure to CPF induces long-lasting alterations in selected sexual-dimorphic responses of the adult social repertoire, and suggest that early exposure to CPF might interfere with hypothalamic neuroendocrine mechanisms regulating social responses. (C) 2008 Elsevier Inc. All rights reserved.
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