Journal
NEUROTOXICOLOGY AND TERATOLOGY
Volume 30, Issue 4, Pages 349-381Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ntt.2007.07.008
Keywords
developmental neurotoxicity testing; DNT; DNT treatment-related effects; interpretation of treatment-related effects
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The reliable detection, measurement, and interpretation of treatment-related developmental neurotoxicity (DNT) effects depend on appropriate study design and execution, using scientifically established methodologies, with appropriate controls to minimize confounding factors. Appropriate statistical approaches should lie optimized for the specific endpoints in advance, analyzing effects across time and functional domains as far as possible. If available, biomarkers of exposure are useful to assess the bioavailabitity of toxicants to the dam and offspring in utero and after birth. Finally, weight of evidence principles are used to aid assessment of the biological significance of differences from concurrent controls. These effects should be interpreted in light of available information from historical controls, positive controls, maternal and offspring systemic toxicity, and other relevant toxicological data. This review provides a framework for the integration of all these types of information in the interpretation of DNT studies. (C) 2007 Elsevier Inc. All rights reserved.
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