Journal
NEUROTOXICOLOGY
Volume 41, Issue -, Pages 141-142Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.neuro.2014.01.010
Keywords
Manganese; In vitro; Brain concentrations; Toxicity
Categories
Funding
- National Institute of Environmental Health Sciences [R01 ES10563, ES016931]
- Molecular Toxicology Center [P30 ES000267]
- NIH grants
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Manganese (Mn) is an environmental risk factor for neuronal dysfunction and neurodegeneration of the basal ganglia and other brain regions. Aberrant brain Mn levels have been linked to manganism, Parkinson's disease (PD), Huntington's disease (HD) and other neurological disorders. Research on the cellular basis of Mn neurotoxicity has relied upon in vitro or non-human model systems. However, an analysis of relevant Mn concentrations for in vitro studies is lacking - and few studies have examined intracellular Mn levels. Here we perform calculations to evaluate in vitro exposure paradigms in relation to relevant in vivo levels of Mn post-exposure. (C) 2014 Elsevier Inc. All rights reserved.
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