Journal
NEUROTOXICOLOGY
Volume 36, Issue -, Pages 82-88Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.neuro.2013.03.008
Keywords
Lead acetate; Hippocampus; Sodium selenite; Learning and memory
Categories
Funding
- National Basic Research Program of China (973 Program) [2012CB525002]
- National Natural Science Foundation of China [81230063, 81001233, 30830087, 30901176]
- Program for New Century Excellent Talents in University
- Science and Technology Innovation Projects of Shaanxi Province [2011KTCL03-19]
- Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT)
- Program of Public Welfare, Ministry of Health, China [200902006]
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The effect of lead (Pb) on spatial memory and hippocampal long-term potentiation (LTP) as a key risk factor has been widely recognized and the oxidative damage has been proposed as a possible mechanism of lead neurotoxicity. Selenium (Se) is a nutritionally essential trace element with known antioxidant potential. In this study we investigated the effect and the underlying mechanisms of Se supplementary on Pb induced cognition and synaptic plasticity impairment. Lactating Sprague-Dawley rats (SD rats) were randomly divided to four groups: 0 ppm lead acetate (Pb); 0 ppm Pb and 0.2 ppm sodium selenite (Se); 100 ppm Pb; 100 ppm Pb and 0.2 ppm Se. Lactating rats were treated with or without Pb and/or Se throughout lactation until weaning. The levels of hippocampal LTP, the spatial memory, the apoptosis of hippocampal neurons, the levels of lactate dehydrogenase (LDH) release, and the serum level of superoxide dismutase (SOD) and malondialdehyde (MDA) were assayed. It had been observed that in Pb group the spatial memory, the induce level of LTP, the serum SOD level decreased, the LDH release level, the neurons apoptosis level, the serum MDA level increased, while in the Se supplements groups, the spatial memory, the induce level of LTP increased significantly. Compared with the Pb group, Se supplements shown down regulated the level of LDH, the neurons apoptosis and the serum MDA, and up regulated the level of serum SOD. We could draw the conclusion that Se supplements could alleviate toxic effect of lead on hippocampal LTP and spatial memory. The treated with selenium around 0.2 ppm may protect against spatial memory dysfunction induced by lead exposure. (c) 2013 Elsevier Inc. All rights reserved.
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