Journal
NEUROTOXICITY RESEARCH
Volume 18, Issue 1, Pages 94-99Publisher
SPRINGER
DOI: 10.1007/s12640-010-9171-5
Keywords
Glutamate transporters; Energy; ATP; Glyceraldehyde-3-P-dehydrogenase; TCA cycle
Categories
Funding
- Danish Medical Research Council [22-03-250, 22-04-0314]
- Lund-beck and Novo Foundations
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It has been proposed that a considerable fraction of glucose metabolism proceeds via the glycogen-shunt consisting of conversion of glucose units to glycogen residues and subsequent production of glucose-1-phosphate to be metabolized in glycolysis after conversion to glucose-6-phosphate. The importance of this as well as the significance of ATP formed in glycolysis versus that formed by the concerted action of the tricarboxylic acid (TCA) cycle processes and oxidative phosphorylation for maintenance of glutamate transport capacity in astrocytes is discussed. It is argued that glycolytically derived energy in the form of ATP may be of particular functional importance in this context.
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