Journal
NEUROTOXICITY RESEARCH
Volume 15, Issue 2, Pages 123-126Publisher
SPRINGER
DOI: 10.1007/s12640-009-9012-6
Keywords
Cell-penetrating peptides; NMDAR; Cerebral ischemia
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Funding
- Swiss National Science Foundation [3100A0-101696, 113925]
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We report in this article for the first time the neuroprotective effects of unconjugated TAT carrier peptide against a mild excitotoxic stimulus both in vitro and in vivo. In view of the widespread use of TAT peptides to deliver neuroprotectants into cells, it is important to know the effects of the carrier itself. Unconjugated TAT carrier protects dissociated cortical neurons against NMDA but not against kainate, suggesting that TAT peptides may interfere with NMDA signaling. Furthermore, a retro-inverso form of the carrier peptide caused a reduction in lesion volume (by about 50%) in a rat neonatal cerebral ischemia model. Thus, even though TAT is designed merely as a carrier, its own pharmacological activity will need to be considered in the analysis of TAT-linked neuroprotectant peptides.
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