Related references
Note: Only part of the references are listed.100 years of Lewy pathology
Michel Goedert et al.
NATURE REVIEWS NEUROLOGY (2013)
Immunotherapy for neurodegenerative diseases: Focus on α-synucleinopathies
Elvira Valera et al.
PHARMACOLOGY & THERAPEUTICS (2013)
Safety and biomarker effects of Solanezumab in patients with Alzheimer's disease
Martin Farlow et al.
ALZHEIMERS & DEMENTIA (2012)
Mechanism of Amyloid Removal in Patients With Alzheimer Disease Treated With Gantenerumab
Susanne Ostrowitzki et al.
ARCHIVES OF NEUROLOGY (2012)
Alzheimer Mechanisms and Therapeutic Strategies
Yadong Huang et al.
CELL (2012)
Monoclonal antibody therapeutics: history and future
Nicholas A. P. S. Buss et al.
CURRENT OPINION IN PHARMACOLOGY (2012)
ß-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment
Jun Cai et al.
EMBO MOLECULAR MEDICINE (2012)
Sustained levels of antibodies against Aβ in amyloid-rich regions of the CNS following intravenous dosing in human APP transgenic mice
Frederique Bard et al.
EXPERIMENTAL NEUROLOGY (2012)
β-Site Amyloid Precursor Protein (APP)-cleaving Enzyme 1 (BACE1)-deficient Mice Exhibit a Close Homolog of L1 (CHL1) Loss-of-function Phenotype Involving Axon Guidance Defects
Brian Hitt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Trans-cellular Propagation of Tau Aggregation by Fibrillar Species
Najla Kfoury et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Clinical trials in Alzheimer's disease': immunotherapy approaches
Julien Delrieu et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Developing ß-secretase inhibitors for treatment of Alzheimer's disease
Arun K. Ghosh et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Antibody-Aided Clearance of Extracellular α-Synuclein Prevents Cell-to-Cell Aggregate Transmission
Eun-Jin Bae et al.
JOURNAL OF NEUROSCIENCE (2012)
An Effector-Reduced Anti-β-Amyloid (Aβ) Antibody with Unique Aβ Binding Properties Promotes Neuroprotection and Glial Engulfment of Aβ
Oskar Adolfsson et al.
JOURNAL OF NEUROSCIENCE (2012)
Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study
Adam S. Fleisher et al.
LANCET NEUROLOGY (2012)
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
Thorlakur Jonsson et al.
NATURE (2012)
Neuronal autoantigens-pathogenesis, associated disorders and antibody testing
Eric Lancaster et al.
NATURE REVIEWS NEUROLOGY (2012)
A Plaque-Specific Antibody Clears Existing β-amyloid Plaques in Alzheimer's Disease Mice
Ronald B. DeMattos et al.
NEURON (2012)
Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
Alix de Calignon et al.
NEURON (2012)
Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease
Randall J. Bateman et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Trans-Synaptic Spread of Tau Pathology In Vivo
Li Liu et al.
PLOS ONE (2012)
A Monoclonal Antibody-GDNF Fusion Protein Is Not Neuroprotective and Is Associated with Proliferative Pancreatic Lesions in Parkinsonian Monkeys
Sachiko Ohshima-Hosoyama et al.
PLOS ONE (2012)
Preventing Alzheimer's Disease
Dennis J. Selkoe
SCIENCE (2012)
Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer's Association Research Roundtable Workgroup
Reisa A. Sperling et al.
ALZHEIMERS & DEMENTIA (2011)
Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein 1
Y. Bertrand et al.
BRITISH JOURNAL OF CANCER (2011)
Introduction to current and future protein therapeutics: A protein engineering perspective
Paul J. Carter
EXPERIMENTAL CELL RESEARCH (2011)
Inhibition of β-Secretase in Vivo via Antibody Binding to Unique Loops (D and F) of BACE1
Lujia Zhou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models REDUCTION OF TAU PATHOLOGY AND DELAY OF DISEASE PROGRESSION
Xiyun Chai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain
Allal Boutajangout et al.
JOURNAL OF NEUROCHEMISTRY (2011)
Robust Amyloid Clearance in a Mouse Model of Alzheimer's Disease Provides Novel Insights into the Mechanism of Amyloid-β Immunotherapy
Allan Wang et al.
JOURNAL OF NEUROSCIENCE (2011)
In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice
Kaoru Yamada et al.
JOURNAL OF NEUROSCIENCE (2011)
Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor
Patrick C. May et al.
JOURNAL OF NEUROSCIENCE (2011)
Autoantibodies associated with diseases of the CNS: new developments and future challenges
Angela Vincent et al.
LANCET NEUROLOGY (2011)
The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
Tharinda W. Rajapaksha et al.
MOLECULAR NEURODEGENERATION (2011)
Receptor-Mediated Abeta Amyloid Antibody Targeting to Alzheimer's Disease Mouse Brain
Qing-Hui Zhou et al.
MOLECULAR PHARMACEUTICS (2011)
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
Eric Karran et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Engaging neuroscience to advance translational research in brain barrier biology
Edward A. Neuwelt et al.
NATURE REVIEWS NEUROSCIENCE (2011)
Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift
Todd E. Golde et al.
NEURON (2011)
Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
Eliezer Masliah et al.
PLOS ONE (2011)
Knock-Down of Cathepsin D Affects the Retinal Pigment Epithelium, Impairs Swim-Bladder Ontogenesis and Causes Premature Death in Zebrafish
Carlo Follo et al.
PLOS ONE (2011)
Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice
Mian Bi et al.
PLOS ONE (2011)
A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo
Jasvinder K. Atwal et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Alzheimer's Disease: The Challenge of the Second Century
David M. Holtzman et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Testing the Right Target and Right Drug at the Right Stage
Reisa A. Sperling et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
Y. Joy Yu et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease
Randall J. Bateman et al.
ALZHEIMERS RESEARCH & THERAPY (2011)
Connecting Vascular and Nervous System Development: Angiogenesis and the Blood-Brain Barrier
Stephen J. Tam et al.
ANNUAL REVIEW OF NEUROSCIENCE, VOL 33 (2010)
Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice
Moran Boimel et al.
EXPERIMENTAL NEUROLOGY (2010)
Induction of Protective Immunity by Vaccination With Wild-Type Apo Superoxide Dismutase 1 in Mutant SOD1 Transgenic Mice
Shigeko Takeuchi et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2010)
Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model
Allal Boutajangout et al.
JOURNAL OF NEUROSCIENCE (2010)
11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study
Juha O. Rinne et al.
LANCET NEUROLOGY (2010)
Can Alzheimer disease be prevented by amyloid-β immunotherapy?
Cynthia A. Lemere et al.
NATURE REVIEWS NEUROLOGY (2010)
Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases
Reinhard Gabathuler
NEUROBIOLOGY OF DISEASE (2010)
The Genetics of Alzheimer Disease: Back to the Future
Lars Bertram et al.
NEURON (2010)
Curative properties of antibodies against prion protein: A comparative in vitro study of monovalent fragments and divalent antibodies
Coralie Alexandrenne et al.
JOURNAL OF NEUROIMMUNOLOGY (2009)
Aβ Immunotherapy: Intracerebral Sequestration of Aβ by an Anti-Aβ Monoclonal Antibody 266 with High Affinity to Soluble Aβ
Kaoru Yamada et al.
JOURNAL OF NEUROSCIENCE (2009)
The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential
Robert Vassar et al.
JOURNAL OF NEUROSCIENCE (2009)
Multimodal techniques for diagnosis and prognosis of Alzheimer's disease
Richard J. Perrin et al.
NATURE (2009)
Transmission and spreading of tauopathy in transgenic mouse brain
Florence Clavaguera et al.
NATURE CELL BIOLOGY (2009)
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
Paula Desplats et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
CNS Delivery Via Adsorptive Transcytosis
Francoise Herve et al.
AAPS JOURNAL (2008)
Active and passive immunotherapy for Neurodegenerative disorders
David L. Brody et al.
ANNUAL REVIEW OF NEUROSCIENCE (2008)
GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier
Ruben J. Boado et al.
BIOTECHNOLOGY AND BIOENGINEERING (2008)
Developing drugs that can cross the blood-brain barrier: applications to Alzheimer's disease
William A. Banks
BMC NEUROSCIENCE (2008)
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
Jia-Yi Li et al.
NATURE MEDICINE (2008)
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
Jeffrey H. Kordower et al.
NATURE MEDICINE (2008)
β-secretase as a therapeutic target for Alzheimer's disease
Arun K. Ghosh et al.
NEUROTHERAPEUTICS (2008)
Targeting β-amyloid pathology in Alzheimer's disease with Aβ immunotherapy
Roger M. Nitsch et al.
NEUROTHERAPEUTICS (2008)
A Unique Carrier for Delivery of Therapeutic Compounds beyond the Blood-Brain Barrier
Delara Karkan et al.
PLOS ONE (2008)
Amyloid precursor protein regulates brain apolipoprotein e and cholesterol metabolism through lipoprotein receptor LRP1
Qiang Liu et al.
NEURON (2007)
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
Ayodeji A. Asuni et al.
JOURNAL OF NEUROSCIENCE (2007)
Anti-amyloid beta protein antibody passage across the blood-brain barrier in the SAMP8 mouse model of Alzheimer's disease: An age-related selective uptake with reversal of learning impairment
William A. Banks et al.
EXPERIMENTAL NEUROLOGY (2007)
Drug development for CNS disorders: strategies for balancing risk and reducing attrition
Menelas N. Pangalos et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and Aβ fibril disaggregation
Ruben J. Boado et al.
BIOCONJUGATE CHEMISTRY (2007)
Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis
Makoto Urushitani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier
Ruben J. Boado et al.
BIOTECHNOLOGY AND BIOENGINEERING (2007)
Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; Importance for CNS drug discovery and development
Sumio Ohtsuki et al.
PHARMACEUTICAL RESEARCH (2007)
Functional effectiveness of the blood brain barrier to small water-soluble molecules in developing and adult opossum (Monodelphis domestica)
CJ Ek et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2006)
Targeted brain delivery of AZT via transferrin anchored pegylated albumin nanoparticles
V Mishra et al.
JOURNAL OF DRUG TARGETING (2006)
The critical component to establish in vitro BBB model: Pericyte
CH Lai et al.
BRAIN RESEARCH REVIEWS (2005)
The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells
A Abulrob et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability
AP Lillis et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2005)
Intravesicular localization and exocytosis of α-synuclein and its aggregates
HJ Lee et al.
JOURNAL OF NEUROSCIENCE (2005)
Effects of α-synuclein immunization in a mouse model of Parkinson's disease
E Masliah et al.
NEURON (2005)
Endocytic recycling
FR Maxfield et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
XP13512 [(±)-1-([(α-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug:: I.: Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters
KC Cundy et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Nanoparticle surface charges alter blood-brain barrier integrity and permeability
PR Lockman et al.
JOURNAL OF DRUG TARGETING (2004)
DNA vaccination against mutant huntingtin ameliorates the HDR6/2 diabetic phenotype
TW Miller et al.
MOLECULAR THERAPY (2003)
Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice
M Koike et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2003)
Passage of amyloid β protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease
WA Banks et al.
PEPTIDES (2002)
Immunization delays the onset of prion disease in mice
EM Sigurdsson et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
Brain to plasma amyloid-β efflux:: a measure of brain amyloid burden in a mouse model of Alzheimer's disease
RB DeMattos et al.
SCIENCE (2002)
Drug and gene targeting to the brain with molecular Trojan horses
WM Pardridge
NATURE REVIEWS DRUG DISCOVERY (2002)
Restricted transport of anti-transferrin receptor antibody (OX26) through the blood-brain barrier in the rat
T Moos et al.
JOURNAL OF NEUROCHEMISTRY (2001)
BACE knockout mice are healthy despite lacking the primary β-secretase activity in brain:: implications for Alzheimer's disease therapeutics
SL Roberds et al.
HUMAN MOLECULAR GENETICS (2001)
Conjugation of brain-derived neurotrophic factor to a blood-brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of tbe neurotrophin
Y Zhang et al.
BRAIN RESEARCH (2001)
Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications
SJ Lee et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2001)
Astrocytes increase the functional expression of P-glycoprotein in an in vitro model of the blood-brain barrier
PJ Gaillard et al.
PHARMACEUTICAL RESEARCH (2000)
Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
F Bard et al.
NATURE MEDICINE (2000)
Transferrin and transferrin receptor function in brain barrier systems
T Moos et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2000)