Journal
NEUROTHERAPEUTICS
Volume 10, Issue 4, Pages 647-663Publisher
SPRINGER
DOI: 10.1007/s13311-013-0229-y
Keywords
Epigenetics; CNS; chromatin; neurodegeneration; aging; histone code; HDAC; DNA methylation
Funding
- NIH [R21 AG043921]
- Buck Institute Trust
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This review highlights recent discoveries that have shaped the emerging viewpoints in the field of epigenetic influences in the central nervous system (CNS), focusing on the following questions: i) How is the CNS shaped during development when precursor cells transition into morphologically and molecularly distinct cell types, and is this event driven by epigenetic alterations?; ii) How do epigenetic pathways control CNS function?; iii) What happens to epigenetic memory during aging processes, and do these alterations cause CNS dysfunction?; iv) Can one restore normal CNS function by manipulating the epigenome using pharmacologic agents, and will this ameliorate aging-related neurodegeneration? These and other still unanswered questions remain critical to understanding the impact of multifaceted epigenetic machinery on the age-related dysfunction of CNS.
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