Journal
NEUROTHERAPEUTICS
Volume 7, Issue 1, Pages 100-114Publisher
SPRINGER
DOI: 10.1016/j.nurt.2009.10.019
Keywords
Blast injury; diffused axonal injury; intracranial pressure; loss of consciousness; post-concussive symptoms; PTSD
Funding
- National Institutes of Health
- Mission Connect/TIRR Foundation [NS35457, NS049160, MH072933, CDMRP: W81XWH-08-2-0134, R38OT10585]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH072933] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS035457, R01NS049160] Funding Source: NIH RePORTER
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Traumatic brain injury (TBI) remains a serious health concern, and TBI is one of the leading causes of death and disability, especially among young adults. Although preventive education, increased usage of safety devices, and TBI management have dramatically increased the potential for surviving a brain injury, there is still a need to develop reliable methods to diagnose TBI, the secondary pathologies associated with TBI, and predicting the outcomes of TBI. Biomarkers (changes of amount or activity in a biomolecule that reflect injury or disease) have shown promise in the diagnosis of several conditions, including cancer, heart failure, infection, and genetic disorders. A variety of proteins, small molecules, and lipid products have been proposed as potential biomarkers of brain damage from TBI. Although some of these changes have been reported to correlate with mortality and outcome, further research is required to identify prognostic biomarkers. This need is punctuated in mild injuries that cannot be readily detected using current techniques, as well as in defining patient risk for developing TBI-associated secondary injuries.
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